•  
     

    Your first drink of the night for a better tomorrow

    Genetically engineered by a team of PhD microbiologists, ZBiotics® Pre-Alcohol is a probiotic drink that breaks down the byproduct of alcohol responsible for rough mornings after drinking.

Pre-Drink Probiotic for Hangover Relief

ZBiotics is the world's first genetically engineered probiotic drink. Taken before alcohol, it helps break down acetaldehyde - the toxin causing hangovers. Feel better tomorrow. Enjoy today, responsibly.

SHOP NOW
  • ★★★★★

    "lt was a lifesaver at my bachelor party and it was a life saver at my wedding. You should have seen the look on my groomsmen's faces when l pulled out a fresh box of ZBiotics.”

    Christopher

  • ★★★★★

    "I cannot begin to explain how amazing this stuff is. lt's the perfect thing that you need for either a night out with the girls or a big trip where you plan on having a lot of alcohol.l will never not have a bottle handy."

    Emily

  • ★★★★★

    "Solid product that does what it says it's supposed to do. Worth every penny."



    Matthew

  • ★★★★★

    "This product is a fail safe for having a great time and fearing for the next day. Especially when you have to deal with your kids the next day!"

    Michal

  • ★★★★★

    "I'm usually skeptical of supplements doing what they claim, but this one works, so l've bumped up the frequency of my order."

    Neil

  • ★★★★★

    "The miracles of modern technology are akin to magic and this is basically a magic potion."



    Daniel

    How it works

    1

    Drink a Pre-Alcohol

    For best results, make Pre-Alcohol your first drink of the night.

    2

    Drink responsibly

    Whether it’s a glass of wine with dinner or going out with friends, pace yourself, hydrate, and get a good night’s sleep.

    3

    Enjoy tomorrow

    Seize your next day—hit the gym, get outside, play with the kids—make the most of it.

    The Problem

    Acetaldehyde is an unwanted molecule that can build up in the body when drinking alcohol

    Here’s the problem. The body has many biological reactions to drinking alcohol, not all of which are pleasant. The metabolism of alcohol produces a variety of small molecules and cellular responses which, when piled-up, can be hard on your body and throw you off your healthy routine. One of those small molecules is acetaldehyde, an unwanted, toxic byproduct of alcohol metabolism. Its chemical structure is highly reactive, which means it can interact with a whole host of molecular and cellular components throughout our bodies. But how does alcohol become acetaldehyde?

    It's not magic,It's science

     

    Alcohol produces acetaldehyde

    When we drink, our bodies break down alcohol into an unwanted byproduct called acetaldehyde.

    That byproduct is largely responsible for how we feel the day after drinking.

    Acetaldehyde builds up in the gut

    Acetaldehyde forms in two places: the liver and the gut.

    The liver produces an enzyme that removes it quickly. But the gut does not. So acetaldehyde builds up and lingers, filtering out into the rest of our body over time.

    Pre-Alcohol breaks it down

    Pre-Alcohol helps our gut catch up by temporarily adding a probiotic that can break down acetaldehyde.

    This probiotic – Bacillus subtilis ZB183™ – has been engineered to produce the same type of enzyme as our liver: one that digests acetaldehyde.

    Proudly built with genetic engineering

    The ZBiotics team invented the probiotic in Pre-Alcohol – Bacillus subtilis ZB183™ – using genetic engineering.

    Our approach to biotechnology is safety-first and grounded in the strictest ethical principles. We build responsibly or we don’t build at all. Pre-Alcohol undergoes rigorous quality testing at every stage.

    The Solution

    Probiotics can be engineered to break down acetaldehyde in the gut

    If you’re trying to enable the gut microbiome to break down acetaldehyde, the most straightforward approach would be to make a bunch of the same enzyme your liver uses (ALDH) and deliver it to the gut, mimicking exactly what your body already does so effectively. Unfortunately, in this case (and most cases really) we can’t just eat an enzyme to equip our bodies with new traits. Enzymes are proteins, and most proteins you consume will break down very quickly as food in your stomach. Once broken down they lose their function.

    But our scientists knew three very interesting things: 

    1. There are probiotic bacteria that can survive the harsh environment of the stomach unharmed. 
    2. Many bacteria are capable of making ALDH – the very enzyme our livers use to break down acetaldehyde.
    3. We can use genetic engineering to create a probiotic bacteria with the ability to make ALDH!

    So rather than trying to solve the problem with an enzyme that won’t survive in the gut, we can instead use genetic engineering to build a probiotic bacteria that not only makes the enzyme but can also deliver it safely to where it's most needed to break down acetaldehyde!

    Though the actual building and testing behind our engineered ZB183™ strain took years, here is what we did on a basic level: We started with a natural probiotic bacteria called Bacillus subtilis. Humans have been intentionally consuming B. subtilis as a probiotic in supplements and fermented foods (e.g. natto, kombucha, etc.) for centuries. B. subtilis also has the natural ability to pass through your stomach acid unharmed and make enzymes in your gut. We then used a process naturally honed by bacteria to insert the instructions for making ALDH into the bacteria’s genome, carefully selecting a location that optimizes the expression of this enzyme. The result was ZB183™ – a probiotic strain of B. subtilis that is identical in every way to the one humans already consume, but with one additional trait: the ability to break down acetaldehyde.

    Our Mission

    Help people live healthier, richer lives with the world’s first genetically engineered probiotics. By building products that people love, we aim to elevate the GMO conversation and showcase the potential of biology to improve our daily lives.

    Unique products, built with genetic engineering

    We believe in the power of science to make daily life better. Products like Pre-Alcohol do that in ways nothing else can. And they are only possible because of genetic engineering.

    Modern genetic engineering, done responsibly

    Innovation should be responsible, transparent, and trustworthy. That's why we spent years developing the world's first genetically engineered probiotic with rigorous testing and scientific integrity. Since launching in 2019, we've earned the confidence of thousands by delivering real, research-backed results.

    SHOP NOW

     FAQs 

    What is ZBiotics® Pre-Alcohol Probiotic Drink?

    Pre-Alcohol is a beverage containing a patented, genetically engineered probiotic (B. subtilisZB183™) that helps you land on your feet the day after drinking alcohol. It’s engineered to break down an unwanted alcohol byproduct calledacetaldehyde– the main culprit behind rough mornings after drinking.

    How does Pre-Alcohol work?

    Pre-Alcohol is designed to replicate the natural process of your liver, but do it in your gut. We took a normal probiotic bacteria you already eat every day, and we bioengineered it to produce the same type of enzyme your liver produces. That enzyme breaks down acetaldehyde – an unwanted byproduct of alcohol that accumulates in your gut when you drink.

    Your liver does not have access to your gut. But by drinking Pre-Alcohol, the goal is to augment your gut’s natural ability to digest acetaldehyde while you drink and while you sleep – helping you make the most of the next day. Just remember that Pre-Alcohol does not affect intoxication or make alcohol safer to drink, so always drink responsibly.

    When do I drink Pre-Alcohol?

    When you're drinking. The earlier the better.

    The probiotic in Pre-Alcohol needs time to “wake up” in your gut, so we say the earlier the better if you can remember it. We drink Pre-Alcohol just before going out – right before our first drink. But it should be active if you drink it any time during the day or evening. So whether it’s a few hours before drinking, right with your first drink, or even if you’ve already enjoyed a round or two, go for it.

    How long does 1 bottle of Pre-Alcohol last after I drink it?

    The probiotic in Pre-Alcohol is likely to stay in your body for 18-24 hours after you drink it. So one bottle will cover you for a whole day, even if you're starting with brunch mimosas followed by evening plans later on!

    Does Pre-Alcohol expire?

    Pre-Alcohol expires 18 months after bottling. Check the “BB” (Best-By) date on your bottle or box.

    Store Pre-Alcohol at room temperature with the cap on. Do not refrigerate. Do not open it until you’re ready to drink it; opening it could potentially let contaminants from the air into the bottle.

    Is Pre-Alcohol FDA-compliant?

    Yes. Pre-Alcohol is fully FDA-compliant for safety and adheres to all regulatory requirements for sale in the U.S.

    Note that FDA compliance is not FDA approval. FDA approval is a process reserved for drug products. Pre-Alcohol is a food/beverage product and has not been approved as efficacious for any purpose by the FDA.

    FDA-compliant for safety means that we’ve satisfied all regulatory requirements to ensure Pre-Alcohol is safe and can be legally sold in the United States. That means that all our manufacturing is conducted in an FDA-registered food-grade facility according to Good Manufacturing Practices compliant with 21 CFR 117. It also means that our novel ingredient – Bacillus subtilis ZB183™ – has been extensively tested and is generally recognized, among qualified experts, as having been adequately shown to be safe under the conditions of its intended use.

    Does Pre-Alcohol affect my level of intoxication?

    No.

    Pre-Alcohol will not affect your level of intoxication. Pre-Alcohol does not decrease your blood alcohol level, nor does it make alcohol any safer.

    All the same rules about alcohol safety apply.  Don’t get behind the wheel, don't operate heavy machinery, and don't drink too much. Alcohol is still dangerous on its own.

    Will Pre-Alcohol change my microbiome?

    That's not how it's designed.

    We intentionally designed Pre-Alcohol so that it would not change your microbiome. We purposefully built our probiotic using a base bacteria that is well-adapted to passing straight through you and not colonizing your gut.

    This creates a few likely benefits: (1) your microbiome remains unchanged; (2) the interaction between our probiotic and your gut should remain consistent and predictable; and (3) because we’re not trying to change your microbiome, we don’t need to use an excessive amount of probiotic per serving.